Article
Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2004
Beger Carmela, Ramadani Marco, Meyer Stephan, Leder Gerd, Krüger Martin, Welte Karl, Gansauge Frank, Beger Hans G
Abstract excerpt
PURPOSE: BRCA1 and BRCA2 are considered to be breast cancer susceptibility genes that may also contribute to pancreatic cancer development because family studies revealed mutation carriers to have an increased risk of developing pancreatic cancer. However, as demonstrated for breast and ovarian cancer, inactivation of BRCA in sporadic diseases is based on alteration in gene expression or functional alteration....
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