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Article

Infection with an Endemic Human Herpesvirus Disrupts Critical Glial Precursor Cell Properties

19 May 2004

Abstract excerpt

Human herpesvirus 6 (HHV-6), a common resident virus of the human CNS, has been implicated in both acute and chronic inflammatory--demyelinating diseases. Although HHV-6 persists within the human CNS and has been described to infect mature oligodendrocytes, nothing is known about the susceptibility of glial precursors, the ancestors of myelin-producing oligodendrocytes, to viral infection. We show that HHV-6...

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PMID: 15152048
DOI: 10.1523/jneurosci.5584-03.2004

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