Article
Association between melanoma and dermal mast cell prevalence in sun-unexposed skin.
The British journal of dermatology - 1 May 2004
Grimbaldeston M A, Pearce A L, Robertson B O, Coventry B J, Marshman G, Finlay-Jones J J, Hart P H
Abstract excerpt
BACKGROUND: Both exposure to intermittent intense sunlight during childhood and ultraviolet (UV) radiation-induced immunomodulation have been directly associated with melanoma development. In mice, the prevalence of dermal mast cells determines susceptibility to UVB-induced systemic suppression of contact hypersensitivity responses and thus may affect immunological responses to melanoma antigens. OBJECTIVES: To...
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