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Article

XLαs, the extra-long form of the α-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex

17 May 2004

Abstract excerpt

Because of the use of alternate exons 1, mammals express two distinct forms of Gsalpha-subunits: the canonical 394-aa Gsalpha present in all tissues and a 700+-aa extra-long alphas (XLalphas) expressed in a more restricted manner. Both subunits transduce receptor signals into stimulation of adenylyl cyclase. The XL exon encodes the XL domain of XLalphas and, in a parallel ORF, a protein called Alex. Alex...

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Identifiers

PMID: 15148396
DOI: 10.1073/pnas.0308758101

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Related research

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XLαs, the extra-long form of the α-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion AlexPMID 15148396Read ↗

Relative functions of Gαs and its extra-large variant XLαs in the endocrine system.Semantic proximity Read ↗

The Alternative Stimulatory G Protein α-Subunit XLαs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult MiceSemantic proximity Read ↗

Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formationSemantic proximity Read ↗

The Distinct Role of the Extra-Large G Protein ɑ-Subunit XLɑs.Semantic proximity Read ↗

Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit.Semantic proximity Read ↗

A paternally inherited non-sense variant c.424G>T (p.G142*) in the first exon of XLαs in an adult patient with hypophosphatemia and osteopetrosis.Semantic proximity Read ↗

Mouse Gnal transcripts and transcriptomics in isolated dystoniaSemantic proximity Read ↗

Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism IbSemantic proximity Read ↗

Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse.Semantic proximity Read ↗

Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.Semantic proximity Read ↗

New Mutations at the Imprinted <i>Gnas</i> Cluster Show Gene Dosage Effects of Gs <i>α</i> in Postnatal Growth and Implicate XL <i>α</i> s in Bone and Fat Metabolism but Not in SucklingSemantic proximity Read ↗

The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.Semantic proximity Read ↗

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