Article
Prophylactic effect of recombinant factor VIIa in factor VII deficient patients.
British journal of haematology - 1 May 2004
Mathijssen Natascha C J, Masereeuw Rosalinde, Verbeek Kitty, Lavergne J Maurice, Costa Jean-Marc, van Heerde Waander L, Nováková Irena R O
Abstract excerpt
Inherited factor VII (FVII) deficiency is a rare autosomal recessive disorder associated with a bleeding tendency. We describe three patients with congenital FVII deficiency who have been treated with activated recombinant factor VII (rVIIa). Two patients had novel mutations and were treated prophylactically with 1.2 mg rVIIa two to three times a week. Patients 1 and 2 had a severe bleeding tendency. The...
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