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Article

No-effect level in the mutagenic activity of the drug cyproterone acetate in rat liver. Part I. Single dose treatment.

Mutation research - 4 Jun 2004

Topinka Jan, Oesterle Doris, Reimann Roland, Wolff Thomas

Abstract excerpt

The anti-androgen and progestagen cyproterone acetate (CPA) is known to cause liver tumors in rats. The drug has been identified recently as a mutagen in the liver of female transgenic lambdalacI (Big Blue) rats at high doses after an expression time of 6 weeks. A dose of 50 mg CPA/kg BW, however, did not increase the mutation frequency (MF) of controls indicating a no-effect level of mutagenicity [Carcinogenesis...

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Identifiers

PMID: 15135643
DOI: 10.1016/j.mrfmmm.2004.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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