A new but frequent mutation of apoB-100-apoB His3543Tyr.

doi:10.1016/j.atherosclerosis.2003.12.021

Article

A new but frequent mutation of apoB-100-apoB His3543Tyr.

Atherosclerosis - 1 May 2004

Soufi Muhidien, Sattler Alexander M, Maerz Winfried, Starke Alexander, Herzum Matthias, Maisch Bernhard, Schaefer Juergen R

Abstract excerpt

ApolipoproteinB 100 (apoB-100) is an important component of atherogenic lipoproteins such as LDL and serves as a ligand for the LDL-receptor. Familial defective apolipoproteinB 100 (FDB) is caused by a R3500Q mutation of the apoB gene and results in decreased binding of LDL to the LDL-receptor. So far FDB is the most frequent and best studied alteration of apoB-100. Apart from this, three other apoB mutations,...

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A new but frequent mutation of apoB-100-apoB His3543Tyr.

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A new but frequent mutation of apoB-100-apoB His3543Tyr.

Abstract excerpt

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