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Article

No benefit to continue lamivudine therapy after emergence of YMDD mutations.

Antiviral therapy - 1 Apr 2004

Liaw Yun-Fan, Chien Rong-Non, Yeh Chau-Ting

Abstract excerpt

BACKGROUND: Mutations in the sequence of the conserved tyrosine-methionine-aspartate-aspartate (YMDD) locus of the HBV RNA-dependent DNA polymerase (rt M 204 I/V) may develop after 6-9 months of lamivudine therapy. The current practice of continuing lamivudine therapy has been associated with hep...

Read the complete abstract on PubMed

Topics

Adolescent
Adult
Amino Acid Motifs
Antiviral Agents
Drug Administration Schedule
Female
Hepatitis B
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lamivudine

Male

Middle Aged

Mutation

RNA-Directed DNA Polymerase

Reverse Transcriptase Inhibitors

Treatment Outcome

Source

Identifiers

PMID: 15134188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15134188-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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No benefit to continue lamivudine therapy after emergence of YMDD mutations.PMID 15134188Read ↗

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