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Article

Developmental effects of von Hippel–Lindau gene deficiency

26 Apr 2004

Abstract excerpt

The histogenetic origin and the basis of the distribution of central nervous system (CNS) hemangioblastomas in the von Hippel-Lindau (VHL) tumor suppressor gene syndrome, VHL disease, are unknown. To better understand hemangioblastoma histogenesis, we analyzed postmortem CNS tissues from four patients with well-established diagnosis of VHL disease including development of characteristic tumors and positive family...

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PMID: 15122713
DOI: 10.1002/ana.20090

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