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Article

Purification and characterization of dihydropyrimidine dehydrogenase from human liver.

1 Oct 1992

Abstract excerpt

Although dihydropyrimidine dehydrogenase has been purified to varying degrees from several species, very little is known about the human enzyme. The importance of this enzyme has recently been shown with cancer chemotherapy, particularly in patients with genetic deficiency of this enzyme. In the present study, this enzyme was purified 7800-fold to homogeneity from human liver by introducing several novel methods...

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PMID: 1512248
DOI: 10.1016/s0021-9258(18)41899-6

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