BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas.

doi:10.1007/s00428-004-1018-0

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BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas.

Virchows Archiv : an international journal of pathology - 1 Jun 2004

Soares Paula, Trovisco Vítor, Rocha Ana Sofia, Feijão Tália, Rebocho Ana Paula, Fonseca Elsa, Vieira de Castro Inês, Cameselle-Teijeiro José, Cardoso-Oliveira Manuel, Sobrinho-Simões Manuel

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Somatic mutations of the BRAF gene (BRAFV599E and BRAFK600E) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is a...

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BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas.

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