Article
Resistance to amprenavir before and after treatment with lopinavir/ritonavir in highly protease inhibitor-experienced HIV patients.
AIDS (London, England) - 2 Jan 2004
Hasson Hamid, Gianotti Nicola, Danise Anna, Seminari Elena, Boeri Enzo, Nozza Silvia, Castagna Antonella, Lazzarin Adriano
Abstract excerpt
Genotypes in nine highly protease inhibitor (PI)-experienced patients were studied before and after lopinavir/ritonavir (LPV/r) treatment. Resistance to amprenavir was the rule both before and after LPV/r treatment. Treatment with LPV/r can select for the 50 V mutation. In this setting, significant differences in the inference of the amprenavir phenotype from genotype were observed when using different algorithms.
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