Article
Gigaxonin is associated with the Golgi and dimerises via its BTB domain.
Neuroreport - 9 Apr 2004
Cullen Valerie C, Brownlees Janet, Banner Steven, Anderton Brian H, Leigh P Nigel, Shaw Christopher E, Miller Christopher C J
Abstract excerpt
Mutations in the gigaxonin gene cause giant axonal neuropathy. The amino-terminus of gigaxonin contains a BTB domain but no binding partners for this domain have so far been identified. Here, we demonstrate that the gigaxonin BTB domain forms homodimers. Other BTB-bearing proteins have also been shown to dimerise via their BTB domains with the dimers then capable of interacting with other ligands. Thus, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.