Article
Biochemical characterization of torsinB.
Brain research. Molecular brain research - 23 Aug 2004
O'Farrell Casey, Lockhart Paul J, Lincoln Sarah, De Lucia Michael, Singleton Andrew B, Dickson Dennis W, Cookson Mark R
Abstract excerpt
Mutations in torsinA, a member of the AAA+ family of ATPases, are associated with early onset-dystonia. A closely related homologue, torsinB, has also been described but the significance of this second form is not clear. Here, we demonstrate that in transfected cells, torsinB has similar electrophoretic mobility to torsinA but is more basic consistent with predictions from the cDNA sequence. Like torsinA, torsinB...
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