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The PmlI-PmlR Quorum-Sensing System in <i>Burkholderia pseudomallei</i> Plays a Key Role in Virulence and Modulates Production of the MprA Protease

2 Apr 2004

Abstract excerpt

Burkholderia pseudomallei is the causative agent of melioidosis, an often fatal infection of humans and animals. The virulence of this pathogen is thought to depend on a number of secreted proteins, including the MprA metalloprotease. We observed that MprA is produced upon entry into the stationary phase, when the cell density is high, and this prompted us to study cell density-dependent regulation in B....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15060030
DOI: 10.1128/jb.186.8.2288-2294.2004

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