Article
Investigation of polymorphisms in the CREM gene in panic disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2004
Hamilton Steven P, Slager Susan L, Mayo David, Heiman Gary A, Klein Donald F, Hodge Susan E, Fyer Abby J, Weissman Myrna M, Knowles James A
Abstract excerpt
Clinical and animal studies suggest a role for pathways regulated by cyclic-AMP in anxiety. Mouse gene deletion studies, our own linkage findings on chromosome 10, and a recently published genetic association study by Domschke et al. [2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. We have employed a family-based design to investigate...
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