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Article

Association of a duplicated repeat polymorphism in the 5'-untranslated region of the DRD4 gene with novelty seeking.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2004

Rogers Geraldine, Joyce Peter, Mulder Roger, Sellman Douglas, Miller Allison, Allington Melanie, Olds Robin, Wells Elisabeth, Kennedy Martin

Abstract excerpt

Novelty Seeking (NS) is a human personality trait in which impulsive, exploratory, and thrill-seeking behaviors are displayed. Dopaminergic genes have been prime candidates in the search for the genetic factors underlying NS because of the central role that dopamine plays in the brain's reward system. We have investigated whether there is an association between a polymorphic 120 base pairs (bp) repeat that is...

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5' Untranslated Regions
Alcohol Drinking
Bipolar Disorder
Depressive Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exploratory Behavior

Gene Duplication

Receptors, Dopamine D2

Receptors, Dopamine D4

Source

Identifiers

PMID: 15048656
DOI: 10.1002/ajmg.b.20133

Genes

DRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association of a duplicated repeat polymorphism in the 5'-untranslated region of the DRD4 gene with novelty seeking.PMID 15048656Read ↗

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking.Semantic proximity Read ↗

The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking.Semantic proximity Read ↗

Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking.Semantic proximity Read ↗

DRD4 and novelty seeking: results of meta-analyses.Semantic proximity Read ↗

D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects.Semantic proximity Read ↗

No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples.Semantic proximity Read ↗

Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait.Semantic proximity Read ↗

Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics.Semantic proximity Read ↗

The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sampleSemantic proximity Read ↗

Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: haplotype characterization and relevance of the 2-repeat allele.Semantic proximity Read ↗

No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants.Semantic proximity Read ↗

Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene.Semantic proximity Read ↗

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