Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma.

Oncogene - 8 Apr 2004

Menez Jeanne, Le Maux Chansac Béatrice, Dorothée Guillaume, Vergnon Isabelle, Jalil Abdelali, Carlier Marie-France, Chouaib Salem, Mami-Chouaib Fathia

Abstract excerpt

The precise role of alpha-actinin-4 encoding gene (ACTN4) is not very well understood. It has been reported to elicit tumor suppressor activity and to regulate cellular motility. To further assess the function of human ACTN4, we studied a lung carcinoma cell line expressing a mutated alpha-actinin-4, which is recognized as a tumor antigen by autologous CD8(+) cytotoxic T lymphocytes (CTL). Confocal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actinin
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Mice, Nude

Share to Microfilament Proteins

Share to Microscopy, Confocal

Share to Neoplasm Transplantation

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 15048094
DOI: 10.1038/sj.onc.1207347

Genes

ACTN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma.PMID 15048094Read ↗

Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer InvasionSemantic proximity Read ↗

The human non-muscle α-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cellsSemantic proximity Read ↗

RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.Semantic proximity Read ↗

α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of FibroblastsSemantic proximity Read ↗

[Biological role of actinin-4 for cancer invasion and metastasis].Semantic proximity Read ↗

Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution.Semantic proximity Read ↗

Mice deficient in alpha-actinin-4 have severe glomerular disease.Semantic proximity Read ↗

Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin.Semantic proximity Read ↗

A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.