Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD4-Independent Infection of Astrocytes by Human Immunodeficiency Virus Type 1: Requirement for the Human Mannose Receptor

26 Mar 2004

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection occurs in the central nervous system and causes a variety of neurobehavioral and neuropathological disorders. Both microglia, the residential macrophages in the brain, and astrocytes are susceptible to HIV-1 infection. Unlike microglia that express and utilize CD4 and chemokine coreceptors CCR5 and CCR3 for HIV-1 infection, astrocytes fail to express CD4....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15047828
DOI: 10.1128/jvi.78.8.4120-4133.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD4-Independent Infection of Astrocytes by Human Immunodeficiency Virus Type 1: Requirement for the Human Mannose ReceptorPMID 15047828Read ↗

HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytesSemantic proximity Read ↗

CD4-independent entry and replication of simian immunodeficiency virus in primary rhesus macaque astrocytes are regulated by the transmembrane protein.Semantic proximity Read ↗

HIV-1 envelope–receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesSemantic proximity Read ↗

The far-reaching HAND of cART: cART effects on astrocytes.Semantic proximity Read ↗

CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1Semantic proximity Read ↗

Restricted HIV-1 infection of human astrocytes: potential role of nef in the regulation of virus replicationSemantic proximity Read ↗

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophagesSemantic proximity Read ↗

Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4Semantic proximity Read ↗

Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytesSemantic proximity Read ↗

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microgliaSemantic proximity Read ↗

Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.Semantic proximity Read ↗

Monocyte/macrophages and their role in HIV neuropathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.