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Article

Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes.

Diabetes - 1 Apr 2004

Conway Bryan R, Maxwell A Peter, Savage David A, Patterson Chris C, Doran Peter P, Murphy Madeline, Brady Hugh R, Fogarty Damian G

Abstract excerpt

Dysfunction of the actin cytoskeleton is a key event in the pathogenesis of diabetic nephropathy. We previously reported that certain cytoskeletal genes are upregulated in mesangial cells exposed to a high extracellular glucose concentration. One such gene, caldesmon, lies on chromosome 7q35, a r...

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Identifiers

PMID: 15047636
DOI: 10.2337/diabetes.53.4.1162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15047636-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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