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Article

Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary

25 Mar 2004

Abstract excerpt

The process of primordial follicle formation is central to the determination of a woman's reproductive lifespan, and in humans occurs towards the end of mid-gestation. Gene knockout analysis in the mouse has shown that Figla, a transcription factor specifically expressed in germ cells, is essential for oocytes to survive and form primordial follicles. Our objective was to investigate whether a human homologue...

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PMID: 15044608
DOI: 10.1093/molehr/gah056

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