Article
Antiviral efficacy of abacavir in antiretroviral therapy-experienced adults harbouring HIV-1 with specific patterns of resistance to nucleoside reverse transcriptase inhibitors.
Antiviral therapy - 1 Feb 2004
Lanier E Randall, Ait-Khaled Mounir, Scott Janna, Stone Chris, Melby Thomas, Sturge Glenn, St Clair Marty, Steel Helen, Hetherington Seth, Pearce Gillian, Spreen William, Lafon Stephen
Abstract excerpt
OBJECTIVE: To evaluate HIV-1 reverse transcriptase genotypic and phenotypic indicators of resistance to abacavir (ABC) as predictors of ABC antiviral efficacy. DESIGN: The study was a retrospective, combined analysis of five multicentre trials in which ABC was added as a single agent to backgroun...
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