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Article

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.

Journal of cellular biochemistry - 1 Apr 2004

Hill David A, de la Serna Ivana L, Veal Timothy M, Imbalzano Anthony N

Abstract excerpt

BRCA1 is a tumor suppressor gene linked to familial breast and ovarian cancer. The BRCA1 protein has been implicated in a diverse set of cellular functions, including activation of gene expression by the p53 tumor suppressor and control of homologous recombination (HR) during DNA repair. Prior re...

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Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15034933
DOI: 10.1002/jcb.20003

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15034933-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.PMID 15034933Read ↗

The BRG1 ATPase of Human SWI/SNF Chromatin Remodeling Enzymes as a Driver of CancerSemantic proximity Read ↗

SWI/SNF Factors Required for Cellular Resistance to DNA Damage Include ARID1A and ARID1B and Show Interdependent Protein StabilitySemantic proximity Read ↗

SWI/SNF: a chromatin-remodelling complex with a role in carcinogenesis.Semantic proximity Read ↗

SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.Semantic proximity Read ↗

Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex InactivationSemantic proximity Read ↗

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling ComplexSemantic proximity Read ↗

Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignanciesSemantic proximity Read ↗

Effects of tumor-associated mutations on Rad54 functions.Semantic proximity Read ↗

The Expression of the SWI/SNF ATPase Subunits BRG1 and BRM in Normal Human TissuesSemantic proximity Read ↗

SWI/SNF chromatin remodeling and cancer.Semantic proximity Read ↗

Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair.Semantic proximity Read ↗

Human RAD51 paralogue, SWSAP1, fosters RAD51 filament by regulating the anti-recombinase, FIGNL1 AAA+ ATPaseSemantic proximity Read ↗

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