Article
MMP-1 polymorphic expression in aortic endothelial cells: possible role in lesion development in smokers and nonsmokers.
Cardiovascular toxicology - 1 Jan 2004
Nordskog Brian K, Blixt Allison D, Zieske Arthur W, Hellmann Gary M
Abstract excerpt
Matrix metalloproteinase-1 (MMP-1) is involved in the degradation of extra-cellular matrix components and is thought to play a key role in atherogenesis. The objective of the present study was to determine: (1) whether MMP-1 differential gene expression observed in primary cultures of human aortic endothelial cells (HAEC) exposed to cigarette smoke condensate (CSC) was associated with a single nucleotide...
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