Article
Presence of an African beta-globin gene cluster haplotype in normal chromosomes in Sicily.
American journal of hematology - 1 Aug 1992
Ragusa A, Frontini V, Lombardo M, Amata S, Lombardo T, Labie D, Krishnamoorthy R, Nagel R L
Abstract excerpt
African admixture in Sicily has been long suspected because of the presence of the sickle gene. Nevertheless, the degree of African admixture cannot be derived from the study of HbS frequency, since this gene was most likely expanded by the selective pressure of malaria, for a long time endemic to the region. We have examined 142 individuals from the Sicilian town of Butera (12% sickle trait) to search for other...
Topics
- Adolescent
- Africa
- Child
- Chromosomes
- DNA
- Gene Frequency
- Globins
- Haplotypes
- Humans
- Multigene Family
- Phenotype
- Polymorphism, Genetic