Article
The genetic heterogeneity of β-globin gene defects in Sicily reflects the historic population migrations of the island.
Blood cells, molecules & diseases - 15 Apr 2011
Giambona Antonino, Vinciguerra Margherita, Cannata Monica, Cassarà Filippo, Fiorentino Germana, Leto Filippo, Gioco Pina Lo, Renda Disma, Passarello Cristina, Maggio Aurelio
Abstract excerpt
The aim of this study is to update the incidence and the distribution of the globin gene defects causing β-thalassemia and abnormal hemoglobins in Sicily. The data derived from a total of 8875 beta-thalassemia alleles and 1330 variant hemoglobin chromosomes studied in Sicily from 1990 during a hemoglobinopathy control program. Fifty-four beta-globin gene defects were characterized, involving 30 different...
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