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Article

Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas.

Journal of the National Cancer Institute - 17 Mar 2004

Knobbe Christiane B, Reifenberger Julia, Blaschke Britta, Reifenberger Guido

Abstract excerpt

The carboxyl-terminal modulator protein (CTMP) has been identified as a negative regulator of protein kinase B/Akt. Aberrant Akt signaling is frequently observed in glioblastomas, the most common and most malignant glial brain tumors. Because loss of CTMP function and/or expression may remove the...

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PMID: 15026474
DOI: 10.1093/jnci/djh064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15026474-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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