Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment.

doi:10.1007/BF01296569

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Article

Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment.

Digestive diseases and sciences - 1 Aug 1992

Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Yamamoto K, Yotsumoto S

Abstract excerpt

Three hepatitis B virus carriers who were HB(e)Ag negative and having normal liver function developed fulminant hepatitis with evidence of HBV replication following intensive chemotherapy for non-Hodgkin's lymphoma. Each was continuously negative for HB(e)Ag. Analysis of the precore region of HBV isolated from each demonstrated that the HBV of each had a point mutation in the precore region that inhibited the...

Topics

Adult
Antineoplastic Combined Chemotherapy Protocols
Artificial Organs
Base Sequence
Carrier State
DNA, Viral
Female
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Non-Hodgkin

Male

Middle Aged

Molecular Sequence Data

Mutation

Virus Activation

Source

Open in PubMed

Identifiers

PMID: 1499451
DOI: 10.1007/BF01296569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1499451-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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