Inhibition of ShcA isoforms p46/p52Shc enhances HIV-1 replication in CD4+ T-lymphocytes.

Abstract excerpt

HIV-1 infection decreases the number of CD4(+) T-cells, and apoptosis has been suggested among the mechanisms. Proteins of the Shc family are involved in a complex network of signal transduction, differentiation, and apoptotic response to stress in many different cell types. Out of three homologo...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CD4-Positive T-Lymphocytes
• Share to Hydrogen Peroxide
• Share to Immunoblotting