Article
A primary cell culture system for human cytotrophoblasts of proximal cytotrophoblast cell columns enabling in vitro acquisition of the extra-villous phenotype.
Placenta - 1 Jan 2000
Nagamatsu T, Fujii T, Ishikawa T, Kanai T, Hyodo H, Yamashita T, Osuga Y, Momoeda M, Kozuma S, Taketani Y
Abstract excerpt
Cytotrophoblast (CT) differentiation into the extra-villous phenotype is a crucial process in initiating their invasion into the decidua and thereby developing the placenta. However, how CTs differentiate into extra-villous CTs (EVCTs) is not fully elucidated. To address this, a suitable culture model for CTs has been long-sought. But this has been hampered by annoying problems such as; cell aggregation, in vitro...
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