Article
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.
The Journal of biological chemistry - 30 Apr 2004
Kishida Tatsuro, Kostetskii Igor, Zhang Zhibing, Martinez Federico, Liu Pei, Walkley Steven U, Dwyer Nancy K, Blanchette-Mackie E Joan, Radice Glenn L, Strauss Jerome F
Abstract excerpt
The StAR-related lipid transfer (START) domain, first identified in the steroidogenic acute regulatory protein (StAR), is involved in the intracellular trafficking of lipids. Sixteen mammalian START domain-containing proteins have been identified to date. StAR, a protein targeted to mitochondria, stimulates the movement of cholesterol from the outer to the inner mitochondrial membranes, where it is metabolized...
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