Article
Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus.
The Journal of investigative dermatology - 1 Jan 2004
Carrozzo Marco, Uboldi de Capei Mariafederica, Dametto Ennia, Fasano Maria Edvige, Arduino Paolo, Broccoletti Roberto, Vezza Denize, Rendine Sabina, Curtoni Emilio Sergio, Gandolfo Sergio
Abstract excerpt
Most lymphocytes in the lamina propria of oral lichen planus (OLP) lesions express and secrete interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), whereas they do not secret interleukin-4 and -10 or transforming growth factor-beta. We analyzed whether the polymorphisms of several cytokines may influence the susceptibility to OLP. Cytokine typing was performed by a sequence-specific PCR...
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