Article
Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer.
International journal of cancer - 10 Apr 2004
de Vos tot Nederveen Cappel Wouter H, Meulenbeld Hielke J, Kleibeuker Jan H, Nagengast Fokko M, Menko Fred H, Griffioen Gerrit, Cats Annemiek, Morreau Hans, Gelderblom Hans, Vasen Hans F A
Abstract excerpt
In vitro studies suggest that a deficient mismatch repair (MMR) system reduces 5-Fluorouracil cytotoxicity. Colon cancer (CC) in hereditary nonpolyposis colorectal cancer (HNPCC) is due to a dysfunctioning MMR gene that leads to microsatellite instability (MSI). Clinical studies on the efficacy of 5-Fluorouracil (5-FU) in MSI high tumours are contradictory. In a retrospective study, we compared the survival of...
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