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Article

Pneumocandins from Zalerion arboricola. II. Modification of product spectrum by mutation and medium manipulation.

The Journal of antibiotics - 1 Dec 1992

Masurekar P S, Fountoulakis J M, Hallada T C, Sosa M S, Kaplan L

Abstract excerpt

Zalerion arboricola ATCC 20868 produces pneumocandin A0 (L-671,329), a cyclic hexapeptide with a dimethylmyristic acid side chain. This compound has anti-candida and anti-pneumocystis activities. We were interested in looking for other related compounds produced by this organism. To facilitate this search, a simple medium (S2) composed of D-mannitol, peptonized milk, lactic acid, glycine, KH2PO4 and trace...

Topics

Anti-Bacterial Agents
Antifungal Agents
Antiviral Agents
Candida albicans
Chromatography, High Pressure Liquid
Echinocandins
Fermentation
Methylnitronitrosoguanidine
Methylnitrosourea
Microbiological Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitosporic Fungi

Mutation

Peptides

Peptides, Cyclic

Pneumocystis

Source

Identifiers

PMID: 1490877
DOI: 10.7164/antibiotics.45.1867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1490877-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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