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Article

Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2004

Curtin Nicola J, Wang Lan-Zhen, Yiakouvaki Anthie, Kyle Suzanne, Arris Christine A, Canan-Koch Stacie, Webber Stephen E, Durkacz Barbara W, Calvert Hilary A, Hostomsky Zdenek, Newell David R

Abstract excerpt

PURPOSE: Mismatch repair (MMR) deficiency confers resistance to temozolomide, a clinically active DNA-methylating agent. The purpose of the current study was to investigate the reversal mechanism of temozolomide resistance by the potent novel poly(ADP-ribose) polymerase (PARP)-1 inhibitor, AG1436...

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Identifiers

PMID: 14871963
DOI: 10.1158/1078-0432.ccr-1144-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14871963-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.PMID 14871963Read ↗

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