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Article

Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression.

Cancer research - 1 Feb 2004

Plaschke Jens, Krüger Stefan, Jeske Birgit, Theissig Franz, Kreuz Friedmar R, Pistorius Steffen, Saeger Hans D, Iaccarino Ingram, Marra Giancarlo, Schackert Hans K

Abstract excerpt

Mononucleotide repeat sequences are particularly prone to frameshift mutations in tumors with biallelic inactivation of the mismatch repair (MMR) genes MLH1 or MSH2. In these tumors, several genes harboring mononucleotide repeats in their coding region have been proposed as targets involved in tumor progression, among which are also the MMR genes MSH3 and MSH6. We have analyzed the expression of the MSH3 and MSH6...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14871813
DOI: 10.1158/0008-5472.can-03-2807

Genes

MSH3
MLH1
MSH6
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression.PMID 14871813Read ↗

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