Article
Are ATM mutations 7271T-->G and IVS10-6T-->G really high-risk breast cancer-susceptibility alleles?
Cancer research - 1 Feb 2004
Szabo Csilla I, Schutte Mieke, Broeks Annegien, Houwing-Duistermaat Jeanine J, Thorstenson Yvonne R, Durocher Francine, Oldenburg Rogier A, Wasielewski Marijke, Odefrey Fabrice, Thompson Deborah, Floore Arno N, Kraan Jaennelle, Klijn Jan G M, van den Ouweland Ans M W, Wagner Teresa M U, Devilee Peter, Simard Jacques, van 't Veer Laura J, Goldgar David E, Meijers-Heijboer Hanne
Abstract excerpt
Two mutations of the ATM gene were recently suggested to confer breast cancer risks similar to mutations of BRCA1 or BRCA2. Here, we set out to confirm these findings in 961 families with non-BRCA1/BRCA2 breast cancer from diverse geographical regions. We did not detect the ATM 7271T-->G mutation in any family. The ATM IVS10-6T-->G mutation was detected in eight families, which was similar to its frequency among...
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