Article
The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity.
Development (Cambridge, England) - 1 Sept 1992
Goode S, Wright D, Mahowald A P
Abstract excerpt
We have characterized the function of a new neurogenic locus, brainiac (brn), during oogenesis. Homozygous brn females lay eggs with fused dorsal appendages, a phenotype associated with torpedo (top) alleles of the Drosophila EGF receptor (DER) locus. By constructing double mutant females for both brn and top, we have found that brn is required for determining the dorsal-ventral polarity of the ovarian follicle....
Topics
- Animals
- Drosophila melanogaster
- ErbB Receptors
- Female
- Genes, Insect
- Morphogenesis
- Mutation
- Oogenesis
- Phenotype
- Signal Transduction