Article
Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations.
Genomics - 1 Dec 1992
van Duin M, Polman J E, Verkoelen C C, Bunschoten H, Meyerink J H, Olijve W, Aitken R J
Abstract excerpt
The human ZP3 gene, encoding the glycoprotein responsible for sperm-egg recognition, has been cloned using mouse ZP3 DNA as a probe. Genomic and cDNA cloning revealed eight exons, spread over 18 kb, encoding a protein of 424 amino acids with a 67% homology to mouse and hamster ZP3. Southern blotting, gene cloning, and sequence analysis were used to show that ZP3 is not a single-copy gene and that the human genome...
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