Article
Pathway analysis of informative genes from microarray data reveals that metabolism and signal transduction genes distinguish different subtypes of lymphomas.
International journal of oncology - 1 Mar 2004
Mircean Cristian, Tabus Ioan, Kobayashi Tohru, Yamaguchi Motoko, Shiku Hiroshi, Shmulevich Ilya, Zhang Wei
Abstract excerpt
Recent clinicopathological studies identified a unique subgroup of diffuse large B-cell lymphoma (DLBCL) that expresses CD5 on the cell surface. This 'de novo CD5+ DLBCL' comprises 10% of all DLBCL and has a poorer prognosis than CD5- DLBCL. Comparison of gene expression profiles between de novo CD5+ DLBCLs and CD5- DLBCLs shows that de novo CD5+ DLBCL expresses high levels of integrin beta1 in tumor cells and...
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