Article
Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas.
PloS one - 1 Jan 2013
Rosolowski Maciej, Läuter Jürgen, Abramov Dmitriy, Drexler Hans G, Hummel Michael, Klapper Wolfram, Macleod Roderick A F, Pellissery Shoji, Horn Friedemann, Siebert Reiner, Loeffler Markus
Abstract excerpt
Based on the assumption that molecular mechanisms involved in cancerogenesis are characterized by groups of coordinately expressed genes, we developed and validated a novel method for analyzing transcriptional data called Correlated Gene Set Analysis (CGSA). Using 50 extracted gene sets we identified three different profiles of tumors in a cohort of 364 Diffuse large B-cell (DLBCL) and related mature aggressive...
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