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Article

Isolation and Characterization of the Gene Encoding a Novel Factor Xa-directed Anticoagulant from the Yellow Fever Mosquito,Aedes aegypti

1 Aug 1998

Abstract excerpt

Mosquito salivary glands secrete a number of proteins that inhibit mammalian hemostasis and facilitate blood feeding. We have isolated the protein product and corresponding cDNA of a gene designated Anticoagulant-factor Xa (AFXa), that encodes the factor Xa (FXa)-directed anticoagulant of the yellow fever mosquito, Aedes aegypti. The protein was purified partially by cation exchange chromatography and shown by...

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PMID: 9694825
DOI: 10.1074/jbc.273.33.20802

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