Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors.

doi:10.1016/s0014-5793(03)01452-2

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Article

Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors.

FEBS letters - 16 Jan 2004

Holmes David I R, Zachary Ian

Abstract excerpt

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that binds specifically to Flt-1. The biological roles of PlGF and Flt-1 have not yet been defined and the signalling mechanisms mediating cellular actions of PlGF remain poorly understood. In human umbilical vein endothelial cells, VEGF and PlGF induced expression of both full-length FosB mRNA and an alternatively...

Topics

Alternative Splicing
Animals
Base Sequence
Cells, Cultured
DNA Primers
Endothelium, Vascular
Gene Expression Regulation
Genes, fos
Genetic Variation
Humans
Placenta Growth Factor
Pregnancy Proteins
Proto-Oncogene Proteins c-fos
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Transcription, Genetic
Umbilical Veins
Vascular Endothelial Growth Factor A

Source

Open in PubMed

Identifiers

PMID: 14741347
DOI: 10.1016/s0014-5793(03)01452-2

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