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Article

Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives.

Bioorganic & medicinal chemistry letters - 9 Feb 2004

Yoakim C, Bonneau P R, Déziel R, Doyon L, Duan J, Guse I, Landry S, Malenfant E, Naud J, Ogilvie W W, O'Meara J A, Plante R, Simoneau B, Thavonekham B, Bös M, Cordingley M G

Abstract excerpt

A series of 8-heteroarylthiomethyldipyridodiazepinone derivatives were prepared and evaluated for their antiviral profile against wild type virus and the important K103N/Y181C mutant as an indicator for broad activity. 2,6-Dimethylpyridine derivative 16 was found to have a good pharmacokinetic profile in spite of poor metabolic stability in rat liver microsomes.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14741280
DOI: 10.1016/j.bmcl.2003.11.049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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