Article
Isolation and characterization of the canine serotonin receptor 1B gene (htr1B).
Gene - 4 Feb 2004
van den Berg Linda, Imholz Sandra, Versteeg Serge A, Leegwater Peter A J, Zijlstra Carla, Bosma Anneke A, van Oost Bernard A
Abstract excerpt
The serotonin receptor 1B gene (htr1B) has been suggested to be implicated in mental disorders in both humans and other species. We have isolated a canine bacterial artificial chromosome (BAC) clone containing htr1B, revealed the coding and surrounding DNA sequence of canine htr1B and designed primer sets for genomic sequencing of the gene. A mutation scan in 10 dogs revealed five single nucleotide polymorphisms...
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