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Demographic heterogeneity explains age-specific patterns of genetic variance in mortality rates.

Experimental gerontology - 1 Jan 2004

Service Philip M

Abstract excerpt

The genetic variance of mortality rates in Drosophila melanogaster increases with age early in life, but declines at intermediate ages. A simulation study was done in order to evaluate two competing explanations for this age-specific pattern: (1) demographic heterogeneity, and (2) binomial sampling effects. The pattern can be explained by demographic heterogeneity among and within genotypes. In contrast, binomial...

Topics

Aging
Animals
Computer Simulation
Drosophila melanogaster
Genetic Variation
Models, Biological
Mortality
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 14724061
DOI: 10.1016/j.exger.2003.09.014

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