Article
Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer.
Journal of the National Cancer Institute - 7 Jan 2004
Kirchhoff Tomas, Satagopan Jaya M, Kauff Noah D, Huang Helen, Kolachana Prema, Palmer Crystal, Rapaport Hannah, Nafa Khedoudja, Ellis Nathan A, Offit Kenneth
Abstract excerpt
Mutations in BRCA1 and BRCA2 that predispose to breast and ovarian cancer are detected in approximately 2.5% of the Ashkenazi Jewish population. To explore whether carriers of Ashkenazi founder mutations in BRCA1 or BRCA2 have an increased risk for colorectal cancer, we screened 586 unselected As...
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