Article
Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells.
The Journal of biological chemistry - 26 Mar 2004
Ogushi Ken-ichi, Wada Akihiro, Niidome Takuro, Okuda Tatsuya, Llanes Rafael, Nakayama Masaaki, Nishi Yoshito, Kurazono Hisao, Smith Kelly D, Aderem Alan, Moss Joel, Hirayama Toshiya
Abstract excerpt
Antimicrobial peptides such as defensins are crucial for host defense at mucosal surfaces. We reported previously that Salmonella enteritidis flagellin (FliC) induced human beta-defensin-2 (hBD-2) mRNA expression in Caco-2 cells via NF-kappaB activation (Ogushi, K., Wada, A., Niidome, T., Mori, N., Oishi, K., Nagatake, T., Takahashi, A., Asakura, H., Makino, S., Hojo, H., Nakahara, Y., Ohsaki, M., Hatakeyama, T.,...
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