Article
Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin.
Endocrinology - 1 Apr 2004
Arimoto-Ishida Emi, Ohmichi Masahide, Mabuchi Seiji, Takahashi Toshifumi, Ohshima Chika, Hayakawa Jun, Kimura Akiko, Takahashi Kazuhiro, Nishio Yukihiro, Sakata Masahiro, Kurachi Hirohisa, Tasaka Keiichi, Murata Yuji
Abstract excerpt
The Forkhead family transcription factor FKHRL1 is an inducer of apoptosis in its unphosphorylated form and was recently reported to be a substrate of Akt kinase. We studied the roles of FKHRL1 in both cisplatin-resistant Caov-3 (a papillary adenocarcinoma cell line) and cisplatin-sensitive A2780 human ovarian cancer cell lines. Treatment of Caov-3 cells but not A2780 cells with cisplatin transiently stimulated...
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