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Article

Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.

Biochemical and biophysical research communications - 16 Jan 2004

Duplomb Laurence, Lee Young, Wang May-Yun, Park Byung H, Takaishi Kiyosumi, Agarwal Anil K, Unger Roger H

Abstract excerpt

To determine if increased local production of glucocorticoids by the pancreatic islets might play a role in the spontaneous noninsulin-dependent diabetes mellitus of obesity, we compared islet 11beta-HSD-1 mRNA and activity in islets of obese prediabetic and diabetic Zucker Diabetic Fatty (ZDF) (...

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Identifiers

PMID: 14697232
DOI: 10.1016/j.bbrc.2003.11.160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14697232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.PMID 14697232Read ↗

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Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats.Semantic proximity Read ↗

Glucocorticoid receptor changes associate with age in the paraventricular nucleus of type II diabetic rat model.Semantic proximity Read ↗

Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB.Semantic proximity Read ↗

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